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Abstract #2232

Multi-Parametric Stroke Imaging Protocol for Mice Using a 1H Cryo Probe at 9.4 T

Patrick Michael Heiler1, Friederike Lara Vollmar2, Melanie Heilmann1, Andreas Lemke1, Stephen Meairs2, Marc Fatar2, Lothar Rudi Schad1

1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; 2Experimental Neurology, Heidelberg University, Mannheim, Germany

The investigation of rt-PA therapy after MCAo in mice by means of MRI requires adequate resolution for the brain size of about 1 x 1 cm, in measurement times acceptable for follow-up studies. We present a protocol including t2-weighted imaging, diffusion weighted imaging and a TOF angiography using a 1H surface cryo coil at 9.4T. The results demonstrate that rt-PA therapy leads to reperfusion of the MCA and significantly reduces the extension of ischemia. The short measurement time makes the protocol suitable for both, detection of the MCAo success immediately after the surgery and temporal evolution studies after rt-PA therapy.