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Abstract #2238

Validation of T2* Weight Signal Change of Oxygen Challenge as a Potential Better Penumbra Estimation

Fang Du1, Shiliang Huang1, Qiang Shen1, Timothy Q. Duong1

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

Mismatch of diffusion/perfusion by MRI has been used as an estimate of the ischemic penumbra, but there are large parts of the mismatch region appear not to at risk and it was also reported that some of the apparent diffusion coefficient reduction area can be salvaged by early reperfusion. It was proposed that T2* weight signal change of oxygen challenge could be a better penumbra estimation. This study applied OC technique to a group of transient ischemia rats and proved this hypothesis.