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Abstract #2251

Quantification of Carotid Artery Blood Flow Before and After the Acetazolamide Challenge

Josephine Mary Reeve1, Dinesh Selvarajah2, Nyssa Craig1, Paul David Griffiths1, Solomon Tesfaye2, Iain D. Wilkinson1

1Academic Radiology, University of Sheffield, Sheffield, S Yorkshire, United Kingdom; 2Diabetes, Royal Hallamshire Hospital, Sheffield, S Yorkshire, United Kingdom

Cerebrovascular reserve or the ability to vasodilate under stress may be a crucial physiological mechanism, providing increased arterial flux when necessary. This study quantified flow within the internal carotid artery (ICA) in 14 normal young adults before and after administration of a carbonic anhydrase inhibitor (acetazolamide). Quantitative flow assessment was based on a single-slice, multi-phase, fast-field echo sequence. Data was extracted via ROI analysis. Significant increases in velocity, flux, apparent vessel diameter but not heart rate were observed following acetazolamide. This assessment provides an objective in-vivo marker of the functional reserve of the macrovascular supply system.