Abstract #2251
Quantification
of Carotid Artery Blood Flow Before and After the Acetazolamide Challenge
Josephine Mary Reeve1, Dinesh Selvarajah2,
Nyssa Craig1, Paul David Griffiths1, Solomon Tesfaye2,
Iain D. Wilkinson1
1Academic Radiology, University of
Sheffield, Sheffield, S Yorkshire, United Kingdom; 2Diabetes,
Royal Hallamshire Hospital, Sheffield, S Yorkshire, United Kingdom
Cerebrovascular
reserve or the ability to vasodilate under stress may be a crucial
physiological mechanism, providing increased arterial flux when necessary.
This study quantified flow within the internal carotid artery (ICA) in 14 normal young
adults before and after administration of a carbonic anhydrase inhibitor
(acetazolamide). Quantitative flow assessment was based on a single-slice,
multi-phase, fast-field echo sequence. Data was extracted via ROI analysis.
Significant increases in velocity, flux, apparent vessel diameter but not
heart rate were observed following acetazolamide. This assessment provides an
objective in-vivo marker of the functional reserve of the macrovascular
supply system.
