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Abstract #2271

Assessing in Vivo Axonal Transport Rates from Deep Brain Structures in Mouse Models of Human Disease

Taeko Inoue1, Robia G. Pautler1

1Dept. of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, United States

Axonal transport is an important cellular mechanism necessary for the normal function and viability of a neuron. As a result, deficits in axonal transport have become associated with the development and progression of human diseases such as diabetes and neurodegenerative diseases such as Alzheimers disease. Here we demonstrate the potential of Manganese Enhanced MRI (MEMRI) for measuring in vivo deficits of axonal transport in two mouse models of human disease.