Temporal Modulation in Connectivity Within the Salience Network in Autism Spectrum Disorder

Juha Nikkinen¹, Jukka Rahko², Tuomo Starck¹, Jukka Remes¹, Ahmed Abou Elseoud¹, Irma Moilanen², Osmo Tervonen¹, Vesa Kiviniemi¹

Temporal modulation in connectivity within the salience network (SN) has been investigated in autism spectrum disorder (ASD) utilizing group independent component analysis (ICA). Using the ICA mixing matrix time courses, connectivity between the components including SN structures, anterior insula (AI) and anterior cingulate cortex (ACC), was investigated. One IC was found to be focused at AI and ACC structure was shown to be detectable in two ICs, ventral ACC and dorsal ACC. As a result we show that the temporal modulation in connectivity is altered in ASD between the AI and ventral ACC components.