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Abstract #2298

Development of a 17.6T Ultra-High Field BOLD-FMRI Method for Amygdala Related Psychiatric Disorders

Markus Friedrich Hildenbrand1, Stephan Nauroth2, Xavier Helluy1, Philipp Moerchel3, Angelika Schmitt2, Klaus-Peter Lesch2

1Research Center Magnetic Resonance Bavaria (MRB), Wuerzburg, Germany; 2Department of Psychiatry, University of Wuerzburg, Germany; 3Department of Experimental Physics 5, University of Wuerzburg, Germany

For psychiatric disorders being a worldwide strain to individuals and the health care systems and still being without comprehensive therapies, the mouse as model organism is a very promising research approach. Based on the development of a 17.6T ultra-high field BOLD-fMRI method for targeting the amygdala in the mouse brain, an access to serotonin mediated psychiatric diseases has been accomplished. By the usage of predator odor the activation of the amygdala shows a high sensitivity and specificity which yields a very good observation of the location and time devolution of the stimulus in the amygdala over a specified time period.