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Abstract #2303

An Objective Approach to FMRI Assessment of Language Lateralization

David F. Abbott1,2, Anthony B. Waites1,2, Graeme D. Jackson1,3

1Brain Research Institute, Florey Neuroscience Institutes (Austin), Melbourne, Victoria, Australia; 2Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia; 3Departments of Medicine & Radiology, The University of Melbourne, Melbourne, Victoria, Australia

Language lateralization based on fMRI is often used in clinical neurological settings. With most conventional methods, the laterality determined can be dependent on the quality of a particular study and chosen statistical threshold. We present an objective threshold-independent method of assessing when individual patients have statistically atypical language lateralization. We illustrate the method using fMRI of verbal fluency in 34 healthy controls. One could also apply the method to other paradigms or regional assessments; for example the assessment of lateralisation of a different task, or to the assessment of anterior-posterior distribution rather than laterality.