Marcus Belke1, David H. Salat2, Enno Wehrmann1, Katja Menzler1, Ulrike Lengler3, Wolfgang H. Oertel1, Felix Rosenow1, Karsten Krakow3, Susanne Knake1
1Department of Neurology, Philipps-University Marburg, Marburg, Germany; 2Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, United States; 3Brain Imaging Center Frankfurt, University of Frankfurt, Frankfurt, Germany
We investigated association between total intracranial volume (TIV) and the volume of several cortical, subcortical and white matter regions. After an automated parcellation of the brain, a slope was calculated, representing the proportional volume of each structure relative to the TIV. Cortical regions were particularly associated with TIV. The greatest slope of the subcortical regions was found for the brainstem. In a second test gender differences were investigated. Large differences were found between men and women when uncorrected volumes were compared. After correction for the influence of the TIV, no gender differences were found in any of the investigated regions.