Marcus Belke1, David H. Salat2,
Enno Wehrmann1, Katja Menzler1, Ulrike Lengler3,
Wolfgang H. Oertel1, Felix Rosenow1, Karsten Krakow3,
Susanne Knake1
1Department of Neurology,
Philipps-University Marburg, Marburg, Germany; 2Athinoula A.
Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA,
United States; 3Brain Imaging Center Frankfurt, University of
Frankfurt, Frankfurt, Germany
We
investigated association between total intracranial volume (TIV) and the
volume of several cortical, subcortical and white matter regions. After an
automated parcellation of the brain, a slope was calculated, representing the
proportional volume of each structure relative to the TIV. Cortical regions
were particularly associated with TIV. The greatest slope of the subcortical
regions was found for the brainstem. In a second test gender differences were
investigated. Large differences were found between men and women when
uncorrected volumes were compared. After correction for the influence of the
TIV, no gender differences were found in any of the investigated regions.