Wen-Tung Wang1, In-Young Choi1,2,
Jieun Kim1, Sang-Pil Lee1
1Hoglund Brain Imaging Center,
University of Kansas Medical Center, Kansas City, KS, United States; 2Neurology,
Molecular & Integrative Physiology, University of Kansas Medical Center,
Kansas City, KS, United States
Magnetic
resonance imaging is the only modality that can provide sufficient spatial
resolution and image contrast to visualize Alzheimers amyloid plaques
noninvasively. Previously Alzheimers amyloid plaques have been visualized in
images acquired using spin-echo and gradient echo sequences at 7 T and 9.4 T.
At high fields, it has been reported that the increased
susceptibility-related contrast resulted in additional anatomical
information, such as delineation of veins and iron-rich regions in human
brain. In this study, we show that the susceptibility-induced contrast in
gradient-echo phase images can improve detection of amyloid plaques.