Manoj Kumar Sarma1, Rajakumar Nagarajan1,
Michael Albert Thomas1, Judy Hayes2, Jaime Deville3,
Karin Nielsen3, David Michalik4, Whitney B. Pope1,
Margaret A. Keller2
1Radiological Sciences, UCLA, Los
Angeles, CA, United States; 2Pediatrics, Harbor-UCLA Medical
Center, Torrance, CA, United States; 3Pediatrics, UCLA, Los
Angeles, CA, United States; 4Millers Childrens Hospital, Long
Beach, CA, United States
Voxel-based
morphometry was used to compare both gray and white matter volume in
perinatally human immunodeficiency virus (HIV)-infected youth versus healthy
controls. HIV patients had reduced gray matter volume in the bilateral
caudate nucleus, left parietal lobe, but an increase of gray matter volume in
the frontal lobe, posterior temporal lobe, and parietal lobe. Striking white
matter volume reductions were found in the temporal lobe, pons, right
pre-frontal area, corpus callosum and the junction of the thalamus and mid
brain. These findings suggest the sensitivity of VBM in evaluating GM and WM
abnormalities in perinatally HIV-infected youth.
Keywords