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Abstract #2327

Voxel-Based Morphometric Analysis of Gray and White Matter in Perinatally HIV-Infected Youth

Manoj Kumar Sarma1, Rajakumar Nagarajan1, Michael Albert Thomas1, Judy Hayes2, Jaime Deville3, Karin Nielsen3, David Michalik4, Whitney B. Pope1, Margaret A. Keller2

1Radiological Sciences, UCLA, Los Angeles, CA, United States; 2Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States; 3Pediatrics, UCLA, Los Angeles, CA, United States; 4Millers Childrens Hospital, Long Beach, CA, United States

Voxel-based morphometry was used to compare both gray and white matter volume in perinatally human immunodeficiency virus (HIV)-infected youth versus healthy controls. HIV patients had reduced gray matter volume in the bilateral caudate nucleus, left parietal lobe, but an increase of gray matter volume in the frontal lobe, posterior temporal lobe, and parietal lobe. Striking white matter volume reductions were found in the temporal lobe, pons, right pre-frontal area, corpus callosum and the junction of the thalamus and mid brain. These findings suggest the sensitivity of VBM in evaluating GM and WM abnormalities in perinatally HIV-infected youth.