Xia Li1,2, Ann Choe, 2,3, Yurui
Gao3,4, Iwona Stepniewska3, Adam Anderson3,4
1Radiology, Vanderbilt University,
Nashville, TN, United States; 2Institute of Imaging Science,
Vanderbilt University, Nashville, TN, United States; 3Biomedical
Engineering, Vanderbilt University; 4Institute of Imaging
Science,, Vanderbilt University, Nashville, TN, United States
The
light microscopy images have a high spatial resolution and are usually
co-registered to the corresponding MR images in order to make the comparison.
However, there are artifacts, such as tearing, deformation, or disappearance
of tissue fragments, in the stained slices. Those artifacts make the
registration among MR, blockface, and light images more difficult. In this
study, two image post-processing techniques are introduced, which can provide
a better initialization to the nonrigid registration algorithm.