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Abstract #2355

Acute & Sub-Chronic Neuronal Effects of NMDA Receptor Antagonist, Memantine Using Pharmacological Magnetic Resonance Imaging

Sakthivel Sekar1, Marleen Verhoye1, Johan Van Audekerke1, Koen Tahon2, Koen Wuyts3, Claire Mackie3, Michele Giugliano2, Thomas Steckler3, Annemie Van Der Linden1

1Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium; 2Theoritical Neurobiology, University of Antwerp, Antwerp, Belgium; 3Johnson & Johnson Pharmaceuticals Research & Development, Beerse, Belgium

The present study reports on the acute and sub-chronic neuronal effects of the NMDA antagonist memantine on the rat brain measured as BOLD (blood oxygenation level dependent) contrast changes in a pharmacological magnetic resonance imaging (phMRI) study. Corroborative investigations include recording the spontaneous local field potential (LFP) activity in key brain regions (through electrophysiology) and the pharmacokinetics of acute and sub-chronic memantine treatment in blood plasma and the brain.