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Abstract #2360

MR Elastography of the Brain in a Mouse Model of Alzheimer's Disease

Matthew C. Murphy1, Geoffrey L. Curran2, Kevin J. Glaser1, Phillip J. Rossman1, John Huston, III1, Joseph F. Poduslo2, Clifford R. Jack1, Joel P. Felmlee1, Richard L. Ehman1

1Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, United States; 2Department of Neuroscience, Mayo Clinic College of Medicine, Rochester, MN, United States

Magnetic resonance elastography was performed in 5 wild-type (WT) mice and 5 Alzheimers disease (AD) mice. The AD model is a double mutation in amyloid precursor protein and presenilin-1 (APP-PS1), which leads to the extracellular deposition of amyloid protein and the formation of plaques with age. The AD mice were found to have a significantly lower mean stiffness compared to age-matched WT mice with a p-value of less than 0.01. The decrease in stiffness may result from mechanical changes in the extracellular matrix following amyloid deposition.