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Abstract #2379

Combined Vegf and Angiopoietin-1 Gene Transfer Using Aav Vectors After Spinal Cord Injury

Juan Jose Herrera1, Ponnada A. Narayana1

1Diagnostic and Interventional Imaging, The University of Texas Health Science Center at Houston, Houston, TX, United States

A consequence of spinal cord injury is the disruption of spinal vasculature, and it is this disruption that contributes to the initiation of cascade of biochemical events leading to secondary damage from the ischemic and inflammatory responses Using adeno-associated viral vectors engineered to express Ang-1 and or VEGF may stimulate angiogenesis and vessel maturation after spinal injury. Our study indicates that the syngeristic effect of both agents reduces spinal vascular permeability and lesion volume determined by MRI leading to functional recovery.