Meeting Banner
Abstract #2385

Neurochemical Profile of the Rat Lateral Septum Investigated with 1H-MRS

Nathalie Just1,2, Maria-Isabel Cordero Campana3,4, Guillaume Poirier3, Hongxia Lei1,2, Carmen Sandi3, Rolf Gruetter1,5

1LIFMET, CIBM, EPFL, Lausanne, Switzerland; 2Department of Radiology, UNIL, Lausanne, Switzerland; 3Laboratory of Behavioural Genetics, EPFL, Brain and Mind Institute, Lausanne, Switzerland; 4Department of Child and Adolescent Psychiatry, HUG, Geneve, Switzerland; 5Department of Radiology, UNIL and HUG, Lausanne and Geneva, Switzerland

The rat lateral septum has been shown to be involved in the expression of anxiety-behaviors such as those involved in conflict procedures. The neurochemical profile of the lateral septum has however never been characterized using proton magnetic resonance spectroscopy in the rat. In the present work, the neurochemical profile of the rat lateral septum was measured at 9.4T using 1H-MRS demonstrating significant changes compared to similar data measured in unspecific rat brain regions. It appears essential to characterize the metabolic profile of specific brain areas with accuracy using 1H MRS.