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Abstract #2404

Brain Neurochemical Effects of Long-Term Sleep Fragmentation Investigated in Mice at 1

Nathalie Just1,2, Maxime Baud3, Jean-Marie Petit3, Pierre Magistretti3,4, Rolf Gruetter1,5

1LIFMET, CIBM, EPFL, Lausanne, Switzerland; 2Department of Radiology, UNIL, Lausanne, Switzerland; 3Laboratoire de neuronergtique et dynamique cellulaire, EPFL, Lausanne, Switzerland; 4Brain and Mind Institute, Lausanne, Switzerland; 5Department of Radiology, UNIL and HUG, Lausanne and Geneva, Switzerland

The present study examined the effects of sleep fragmentation (SF) in the hippocampus and the cortex of mice using proton MR spectroscopy at 14.1T. Disruptions in brain sensory processing and cognitive performance were seen during sleep fragmentation. Moreover, there is evidence that SF negatively affects memory and learning. Here, significant decreases in GABA and Lactate concentrations were detected in the hippocampus of mice following sleep fragmentation indicating decreased synaptic function in the hippocampus.