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Abstract #2420

Tumor Metabolism and Perfusion in Head and Neck Squamous Cell Carcinoma: Pretreatment Multimodality Imaging with 1H-MRS, DCE MRI and 18F-FDG PET: An Exploratory Study

Jacobus FA Jansen1, Heiko Schoder1, Nancy Lee1, Hilda Stambuk1, Ya Wang1, Matthew Fury1, Snehal Patel1, David Pfister1, Jatin Shah1, Jason Koutcher1, Amita Shukla-Dave1

1MSKCC, NY, United States

The study aims to correlate pretreatment multimodality (MM) imaging data obtained with 1H-MRS, DCE-MRI and 18F-FDG PET in patients with head and neck squamous cell carcinoma (HNSCC) with neck nodal metastases for more precise assessment of the tumor metabolism and perfusion. Additionally, pretreatment MM imaging data was evaluated for its efficacy in prediction of short term response to treatment. In 29 HNSCC patients, Cho/W, Ktrans, ve, kep, 18F-FDG SUV measures were correlated. It was found that pretreatment MM imaging is valuable for the precise assessment of tumor biology, and maybe a predictive marker for short term response.