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Abstract #2441

Impaired Structural Connectivity of Language and Memory Networks in Patients with Chronic Epilepsy

Maarten Vaessen1,2, Jaap Jansen3, Paul Hofman, Marielle Vlooswijk, Henriette Majoie, Mark de Krom, Albert Aldenkamp1,2, Walter Backes

1School for Mental Health and Neuroscience , Maastricht University Medical Centre, Maastricht, Limburg, Netherlands; 2Kempenhaeghe Epilepsy Institute, Heeze, Netherlands; 3Memorial Sloan-Kettering Cancer Center, New York, NY, United States

Patients with chronic epilepsy commonly develop cognitive co-morbidity. Previously, it was observed that their declined cognitive performance was associated with loss of functional connectivity derived from functional MRI of memory and language tasks. In this study we aimed to identify impaired structural connections, obtained with fibre tractography, between brain regions commonly associated with language and memory function. We found that fiber connections between the left and right frontal lobe were significantly reduced in these patients and were correlated with IQ.