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Abstract #2451

Diffusion Tensor Imaging of the Normal and Injured Pediatric Spinal Cord at

Feroze B. Mohamed1, Louis N. Hunter2, Nadia Barakat1, Chia-Shang Liu1, Haris Sair3, Amer Samdani2, Randal Betz2, Scott H. Faro1, John Gaughan1, Mary J. Mulcahey2

1Temple University, Philadelphia, PA, United States; 2Shriners Hospital for Children; 3Massachusetts General Hospital

To measure and establish normative DTI parameters of healthy spinal cord tissue in children with idiopathic scoliosis as a means for comparison with children with spinal cord injury (SCI). 5 subjects with idiopathic scoliosis and 5 subjects with SCI were imaged twice using DTI. The SCI subjects showed reduced FA values and increased D values compared with control subjects. Test-retest reproducibility showed excellent inter class correlation (ICC) in all the control group DTI index values (>0.9) while the SCI group showed moderate ICC (>0.7). There were statistically significant correlations between the DTI indices and several ISNCSCI clinical impairment scores.