Feroze B. Mohamed1, Louis N. Hunter2, Nadia Barakat1, Chia-Shang Liu1, Haris Sair3, Amer Samdani2, Randal Betz2, Scott H. Faro1, John Gaughan1, Mary J. Mulcahey2
To measure and establish normative DTI parameters of healthy spinal cord tissue in children with idiopathic scoliosis as a means for comparison with children with spinal cord injury (SCI). 5 subjects with idiopathic scoliosis and 5 subjects with SCI were imaged twice using DTI. The SCI subjects showed reduced FA values and increased D values compared with control subjects. Test-retest reproducibility showed excellent inter class correlation (ICC) in all the control group DTI index values (>0.9) while the SCI group showed moderate ICC (>0.7). There were statistically significant correlations between the DTI indices and several ISNCSCI clinical impairment scores.