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Abstract #2455

Diffusion Tensor MR Characteristics of Cervical Spondylosis

Benjamin M. Ellingson1,2, Jean-Louis Benae2, Shekar N. Kurpad2, Brian D. Schmit3, Mehmet Kocak1, Marjorie C. Wang2

1Dept. of Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; 2Dept. of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; 3Dept. of Biomedical Engineering, Marquette University, Milwaukee, WI, United States

The objective of the current study was to characterize the diffusion tensor MRI (DTI) properties of the cervical spinal cord in patients diagnosed with cervical spondylosis. Axial DTI was performed throughout the region of highest cord compression in 17 patients with cervical spondylosis using a clinical 1.5T MRI system. Results showed spatially localized regions of high FA and low MD at the site of compression. Longitudinal ADC was significantly lower than historic controls, whereas transverse ADC was significantly higher than historic controls in regions adjacent to the site of compression. Results from this study suggest that FA and MD can be used to localize regions of the spinal cord under the largest degree of compression.