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Abstract #2473

Reduction of Breast Density Following Tamoxifen Treatment Evaluated by 3-D MRI

Jeon-Hor Chen1,2, Yeun-Chung Chang3, Daniel Chang1, Yi-Ting Wang3, Ke Nie1, Ruey-Feng Chang3, orhang Nalcioglu1, Chiun-Sheng Huang3, M-Y Lydia Su1

1Center for Functional Onco-Imaging, UC Irvine, Irvine, CA, United States; 2China Medical University Hospital, Taiwan; 3National Taiwan University, Taiwan

We have demonstrated that the breast density analyzed based on a 3D MR method can be used to investigate the changes associated with tamoxifen treatment. We found a significant reduction in fibroglandular tissue volume and percent breast density after treatment, and the density reduction was positively correlated with the baseline density and treatment duration.