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Abstract #2504

Inflammation Assessment in the Lungs of LPS-Challenged Rodents: Comparison Between Radial Ultra-Short Echo Time (UTE) and Cartesian MR Imaging

Magdalena Zurek1, Laura Carrero-Gonzalez2,3, Selina Bucher2, Thomas Kaulisch2, Detlef Stiller2, Yannick Crmillieux1

1Universit de Lyon, Laboratoire CREATIS-LRMN, Lyon, France; 2Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; 3Universidad Complutense de Madrid, Madrid, Spain

A radial ultra short-echo time (UTE) sequence has been shown to be appropriate in pulmonary imaging due to its robustness against motion and its improved image resolution. In this study, we evaluated the accuracy of edema detection using two protocols based on conventional-Cartesian and UTE radial imaging approaches. Despite degraded image quality in case of Cartesian images due to the motion, similar inflammation extent was found for both approaches. The UTE technique, applied under free-breathing conditions, will certainly prove to be quite useful in routine MR investigations applied on models of lung diseases associated with inflammation or mucous hypersecretion.