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Abstract #2516

Physiological Modelling of Oxygen-Enhanced MRI in the Lung

Josephine Helen Naish1,2, Geoff J M Parker1,2

1Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom; 2Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom

We present a two-compartment model of pulmonary oxygen-enhanced MRI (OE-MRI) based on known gas exchange processes in the lung. The model relates the rate of change of oxygen partial pressure to physiological parameters describing ventilation, perfusion and blood oxygen solubility and allows quantitative V/Q maps to be extracted from OE-MRI data.