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Abstract #2543

Measurement of the Diffusion of Hyperpolarized 129Xe in Human Lungs Over Short and Long Time Scales During One Breath Hold

Chengbo Wang1, John P. Mugler, III1,2, Eduard E. de Lange1, Kai Ruppert1, William F. Hersman3,4, Isabel M. Dregely3, Iulian Ruset, 3,4, Stephen Ketel4, Talissa A. Altes1

1Radiology, University of Virginia, Charlottesville, VA, United States; 2Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 3Physics, University of New Hampshire, Durham, NH, United States; 4Xemed LLC, Durham, NH, United States

Regional ADC maps of hyperpolarized 129Xe in human lungs measured over both short and long time scales and with identical spatial registration during a single breath hold were acquired in 5 human subjects. Measured 129Xe ADC values were about 10% of the corresponding previously reported 3He ADC values for both time scales, similar to the expected difference of 16% due to the differences in diffusivity of the gases. The current SNR of 129Xe MRI is sufficient for diffusion MRI, and 129Xe diffusion MRI has been performed in healthy subjects and subjects with lung disease.