Abstract #2547

Estimation of Rat Lung Surface to Volume Ratio and Xenon Diffusing Capacity Using Hyperpolarized 3He and 129Xe Gases

Matthew S. Fox^1,2, Alexei Ouriadov¹, William Dominguez-Viqueira^1,3, Marcus Couch^1,2, Giles E. Santyr^1,3

¹Imaging, Robarts Research Institute, London, Ontario, Canada; ²Physics and Astronomy Dept, University of Western Ontario, London, Ontario, Canada; ³Medical Biophysics, University of Western Ontario, London, Ontario, Canada

Hyperpolarized ¹²⁹Xe is a novel gaseous contrast agent which also dissolves in the lung parenchyma and blood compartments, offering an interesting palette of potential biomarkers of pulmonary disease. ¹²⁹Xe signals from the dissolved compartments have different chemical shifts and can be selectively saturated and allowed to recovery as a function of delay time as in the chemically selective saturation recovery (CSSR) technique. We collected CSSR data and 3D volumes from rat lungs in-vivo and explore both the Butler and Mansson model for estimations of surface to volume ratio, diffusing capacity and tissue transit time.