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Abstract #2552

Hyperpolarized Xenon-129 Dissolved-Phase Signal Dependence on the Echo Time

Kai Ruppert1, Jaime F. Mata1, Isabel M. Dregely2, Talissa A. Altes1, G Wilson Miller1, Stephen Ketel3, Jeff Ketel3, Iulian C. Ruset3, F William Hersman2, John P. Mugler, III1

1Radiology, University of Virginia, Charlottesville, VA, United States; 2Physics, University of New Hampshire, Durham, NH, United States; 3Xemed, LLC, Durham, NH, United States

Due to the large chemical shift difference between hyperpolarized Xe129 (HXe129) dissolved in lung tissue and in the alveolar air spaces it is feasible to image both compartments simultaneously, appearing side-by-side in the image, by using a suitable imaging bandwidth. By varying the TE of the image acquisition it appears to be feasible to extract additional information about the regional distribution of the dissolved-phase sub-compartments, which might be strongly affected by pulmonary interstitial or vascular diseases. Prelimary results in alive and post mortem rabbits are presented.