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Abstract #2574

Performance of Three Transmitter Calibration Methods for Hyperpolarized Gas MRI in the Presence of B0 and B1 Inhomogeneity

Kun Qing1, Grady Wilson Miller2, John Philip Mugler, 12

1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 2Department of Radiology, University of Virginia, Charlottesville, VA, United States

A low-flip-angle, phase-based method for calibrating the transmitter voltage for hyperpolarized gas MRI has been presented in previous studies. This work introduces two optimized versions of the phase-based method, and evaluates their performance in the presence of B0 and B1 inhomogeneities compared to that for an amplitude-based method. Results show that the accuracy of all three methods is affected by significant B1 inhomogeneity; for significant B0 inhomogeneity, the amplitude-based method is robust while the phase-based methods are very sensitive, particularly at relatively low flip angles.