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Abstract #2582

Improvements in Hepatic Stiffness Assessment with 3-D/3-Axis MR Elastography

Meng Yin1, Kevin J. Glaser1, Jun Chen1, Jayant A. Talwalkar2, Armando Manduca1, Richard L. Ehman1

1Department of Radiology, Mayo Clinic, Rochester, MN, United States; 2Division of Gastroenterology, Mayo Clinic, Rochester, MN, United States

One advantage of liver MR elastography (MRE) over biopsy or ultrasound-based transient elastography is its ability to reduce sampling errors by measuring liver stiffness over a large portion of the liver. While existing 2-D or localized approaches yield valid results in a substantial part of the volume, a full 3-D/3-axis wave analysis is required for valid measurements of stiffness throughout the entire liver. This investigation compares a 2-D and a 3-D approach for liver MRE and demonstrates that 3-D MRE analysis improves the homogeneity of hepatic stiffness estimates.