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Abstract #2592

Flip Angle Optimization with Hepatobiliary Contrast Agents at 3T

Sharon Lisa D'Souza1, Alex P. Frydrychowicz1, Karl K. Vigen1, Scott K. Nagle1, Scott B. Reeder2

1Radiology, University of Wisconsin, Madison, WI, United States; 2Radiology, Medical Physics, Biomedical Engineering, and Medicine, University of Wisconsin, Madison, WI, United States

Gadolinium based contrast agents Gd-EOB-DTPA and Gd-BOPTA have hepatobiliary excretion and tremendous utility for liver lesion characterization and biliary imaging with T1 weighted imaging. Unfortunately, most T1 weighted sequences are not optimized for maximizing CNR in delayed phase hepatobiliary imaging. The purpose of this study was to perform flip angle optimization at 3.0T for delayed hepatobiliary phase imaging as part of a cross-over study comparing Gd-EOB-DTPA and Gd-BOPTA. Data show that imaging at 40-45 FA with 0.05mmol/kg Gd-EOB-DTPA at 20 minutes and 20-25 FA with 0.1mmol/kg Gd-BOPTA provides optimal CNR behavior to visualize the liver and bile ducts.