Benjamin Leporq1, Olivier Beuf1, Denis Grenier1, Frank Pilleul2
1Universit de Lyon, Creatis-LRMN, CNRS UMR 5220, Inserm U630, INSA-Lyon, Universit Lyon 1, Villeurbanne, France; 2Universit de Lyon, Creatis-LRMN, CNRS UMR 5220, Inserm U630, INSA-Lyon, Universit Lyon 1, Hospices Civils de Lyon, Lyon, France
Liver fibrosis is an important cause of mortality and morbidity in patients with chronic liver. A non invasive technique to perform an early detection and a clinical follow-up of liver fibrosis is still needed. The objectives of this study was to evaluate estimated-perfusion parameters based on 1.5T-MR dynamic acquisition with the MS-325 paramagnetic blood pool agent for liver fibrosis diagnosis in comparison with histological findings. Dynamic 3D MRI was performed with a continuous free-breathing acquisition followed by a rigid-images registration. A 5-parameters dual input one compartment model was used to estimate quantitative perfusion parameters. Sixteen patients with chronic liver diseases were prospectively enrolled. Hepatic Perfusion Index and portal blood flow were found relevant parameters to discriminate between F2, F3 and F4 METAVIR stages (p<0.03). Mean transit time and total blood flow between F2, F3 and F4 stages were significantly different (p<0.05). Arterial blood flow allowed only to separate F2, F3, F4 with F0 and F1 stages (p<0.03). High molecular weight of MS-325 complex appears well suited to evaluate liver fibrosis.