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Abstract #2597

Dynamic Contrast-Enhanced MRI in the Liver at 3T with Dual-Input Pharmacokinetic Model Analysis

Andrew Brian Gill1, Lorenzo Mannelli1, Peter Beddy1, Richard T. Black1, Ilse Joubert1, Andrew N. Priest1, Martin J. Graves1, David J. Lomas1

1Dept of Radiology, University of Cambridge & Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

This study reports hepatic perfusion measurements made with DCE-MRI at 3T, performed so as to allow analysis using a dual-input kinetic model which separates perfusion components from the hepatic artery and portal vein. DCE data acquisition had a single-heartbeat time resolution and employed a dual saturation-recovery sequence to sample high [Gd] in the blood near-simultaneously with low [Gd] in the liver parenchyma. Mean results for total perfusion (69 24 ml/min/100ml) and arterial fraction (16 7 %) from 7 healthy volunteers were in line with those reported by other groups collecting data at 1.5T.