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Abstract #2634

No Relation Between Altered Oxidative Mitochondrial Function and Impaired Muscle Perfusion in Type 2 Diabetes

Sandrine Duteil1,2, Sabrina Chiheb3, Claire Wary1,2, Emmanuel Cosson3, Aurlien Monnet1,2, Paul Elie Valensi3, Didier Mesengeau3, Pierre Georges Carlier1,4

1NMR Laboratory, Institute of Myology, F-75651 Paris, France; 2CEA, IBM, MIRCen, IdM NMR Laboratory,, F-75651 Paris, France; 3Endocrinology, Jean Verdier Hospital, F- 93140 Bondy, France; 4CEA, IBM, MIRCen, IdM NMR Laboratory, , F-75651 Paris, France

Microangiopathic complications are a major concern in diabetes mellitus type II. Oxidative phosphorylation may also be impaired, with a yet imprecise relationship to microangiopathy . An integrative investigation of metabolic and vascular response to stress was carried out to determine possible alterations of perfusion and oxidative metabolism in calf muscle of 96 patients, categorized according to incidence of microangiopathy. Combining perfusion, oxygenation and energetic measurements, we could show that mitochondrial activity was altered in patients with poorly controlled glycaemia, but unrelated to reduced perfusion, which was common to all patients, while possible anomalies of oxygen diffusion might reflect diabetic microangiopathy.