Sandrine Duteil1,2, Sabrina Chiheb3,
Claire Wary1,2, Emmanuel Cosson3, Aurlien Monnet1,2,
Paul Elie Valensi3, Didier Mesengeau3, Pierre Georges
Carlier1,4
1NMR Laboratory, Institute of Myology,
F-75651 Paris, France; 2CEA, IBM, MIRCen, IdM NMR Laboratory,,
F-75651 Paris, France; 3Endocrinology, Jean Verdier Hospital, F-
93140 Bondy, France; 4CEA, IBM, MIRCen, IdM NMR Laboratory, ,
F-75651 Paris, France
Microangiopathic
complications are a major concern in diabetes mellitus type II. Oxidative
phosphorylation may also be impaired, with a yet imprecise relationship to
microangiopathy . An integrative investigation of metabolic and vascular
response to stress was carried out to determine possible alterations of perfusion and
oxidative metabolism in calf muscle of 96 patients, categorized according to
incidence of microangiopathy. Combining perfusion, oxygenation and energetic
measurements, we could show that mitochondrial activity was altered in
patients with poorly controlled glycaemia, but unrelated to reduced
perfusion, which was common to all patients, while possible anomalies of
oxygen diffusion might reflect diabetic microangiopathy.
Keywords