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Abstract #2637

Beneficial Effects of Diethylnorspermine in Obesity and Its Cardiac Complications

MingMing Li1, Beau Pontre2, Stephen Pickup3, Hong Xu4, Anthony Philips2, Garth Cooper2, Jun Lu2,5

1School of Biological Sciences, Auckland University, Auckland, New Zealand; 2School of Biological Sciences, Auckland University, New Zealand; 3Department of Radiology, University of Pennsylvania, Philadelphia, United States; 4College of Chemistry and Chemical Engineering, Shen Zhen University, Shenzhen, Guangdong, China; 5NCIECP, Auckland University of Technology, Auckland, New Zealand

We hypothesise that chemically induced Spermidine/spermine acetyl transferase (SSAT) activity, which stimulates polyamine catabolism and in turn enhances fat/glucose metabolism, would decrease fat content and improve cardiac function in obese mice. C57Bl/6 and matched leptin deficiency (ob/ob) mice were treated with a potent SSAT inducer, N1, N11-diethylnorspermine (DENS), through i.p. injection. Results showed that DNES not only can significantly reduce body fat percentages in both mice models, but also can control ob/obs body weight. Moreover, DENS can prevent the development of cardiac hypertrophy in obese mice. Therefore, SSAT is a potential target for the development of pharmacotherapy in obesity.