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Abstract #2652

Impact of Low and High B-Value MR Diffusion in HIV/HCV-Coinfected, HIV-Monoinfected and Uninfected Subjects

Susan Moyher Noworolski1,2, Phyllis Tien3,4, Michelle Nystrom1, Suchandrima Banerjee5, Aliya Qayyum1

1Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States; 2The Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA, United States; 3Medicine, University of California, San Francisco, CA, United States; 4Medicine, Veteran Affairs Medical Center, San Francisco, CA, United States; 5MR Applied Science Lab, GE Healthcare, Menlo Park, CA, United States

The impact of a perfusion regime, low b-value ADC, and a tissue regime, high b-value ADC were evaluated in comparison to a conventional ADC in three groups of subjects: HIV/HCV (hepatitis C) coinfection, HIV-monoinfection, and without infection. Liver ADC was measured using b values of 0 and 150 (ADClow), 150 and 600 (ADChigh) and 0 and 600 (ADCconv) in one breathhold sequence. ADClow and ADChigh provided unique information. HIV tended to have the highest ADC levels and was significantly higher than HIV/HCV for ADClow and ADCconv. HIV status may thus be an important consideration in interpretation of liver ADC.