Abstract #2652

Impact of Low and High B-Value MR Diffusion in HIV/HCV-Coinfected, HIV-Monoinfected and Uninfected Subjects

Susan Moyher Noworolski^1,2, Phyllis Tien^3,4, Michelle Nystrom¹, Suchandrima Banerjee⁵, Aliya Qayyum¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States; ²The Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA, United States; ³Medicine, University of California, San Francisco, CA, United States; ⁴Medicine, Veteran Affairs Medical Center, San Francisco, CA, United States; ⁵MR Applied Science Lab, GE Healthcare, Menlo Park, CA, United States

The impact of a perfusion regime, low b-value ADC, and a tissue regime, high b-value ADC were evaluated in comparison to a conventional ADC in three groups of subjects: HIV/HCV (hepatitis C) coinfection, HIV-monoinfection, and without infection. Liver ADC was measured using b values of 0 and 150 (ADC^low), 150 and 600 (ADC^high) and 0 and 600 (ADC^conv) in one breathhold sequence. ADC^low and ADC^high provided unique information. HIV tended to have the highest ADC levels and was significantly higher than HIV/HCV for ADC^low and ADC^conv. HIV status may thus be an important consideration in interpretation of liver ADC.