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Abstract #2687

Changes in Kidney Volume in Experimental PKD Quantified by a Clinical 3T MR Scanner

Sheryl Foster1, Mayuresh S. Korgaonkar2, Gopi K. Rangan3, Kristina G. Schwensen3, Anthony Peduto1

1Radiology, Westmead Hospital, University of Sydney, Australia; 2Brain Dynamics Center, Westmead Millennium Institute, Westmead, NSW, Australia; 3Centre for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney, Australia

The goal of this study was to assess the feasibility of using a 3T whole body clinical scanner along with a conventional available wrist coil in a longitudinal study of drug treatment in small rodents. We studied longitudinal kidney structural changes in rodents with Polycystic Kidney Disease (PKD); and also evaluated the effect of sirolimus treatment, an immunosuppressant drug currently used in clinical trials in humans with PKD, during early disease on the progression of kidney enlargement in this animal model.