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Abstract #2700

Resistance and Sensitivity to Docetaxel Treatment of Breast Cancer Tissue in Mice Assessed by Analysis of Choline Compounds with HRMAS NMR Spectroscopy

Jack van Asten1,2, Tone F. Bathen3, Tessa Buckle4, Chantal Beekman4, Ingrid Gribbestad3, Fijs van Leeuwen4, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; 2Biophysical Chemistry, Radboud University Nijmegen, Nijmegen, Netherlands; 3Dept. of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 4Radiology and Nuclear Medicine, Division of Diagnostic Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital

Breast cancers may be resistant to docetaxel treatment. We investigated the metabolic profile of breast cancer tissue in mouse strains resistant and sensitive to treatment by docetaxel. A typical choline compound profile was found to be predictive for treatment efficiency.