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Abstract #2721

Comparison of Tracer Kinetic Models with DCE-MRI to Evaluate a Phase 1 Anti-Angiogenic Trial

Choon Hua Thng1, Tong San Koh2, Septian Hartono1, Bee Choo Tai3, Puor Sherng Lee1, Helmut Rumpel4, Ai Bee Ong5, Norita Sukri5, Chiung-Ing Wong5, Ross Soo5, Albert Su Chong Low4, Rod Humerickhouse6, Boon Cher Goh5

1National Cancer Centre Singapore, Singapore, Singapore; 2Nanyang Technological University, Singapore, Singapore; 3National University of Singapore, Singapore; 4Singapore General Hospital, Singapore; 5National University Hospital, Singapore; 6Abbott Laboratories, United States

Dynamic contrast enhanced MRI (DCE-MRI) with tracer kinetic modeling has been proposed as a biomarker of angiogenesis imaging. Three tracer kinetic models were studied as methods of angiogenesis assessment: conventional compartmental (model developed by Brix et al. (1), adiabatic approach to tissue homogeneity model developed by St. Lawrence and Lee (2), and distributed parameter model developed by Koh et al. (3) All models enable derivation of tissue microcirculatory parameters such as blood flow and capillary permeability-surface area product. We aim to examine the association between the above parameters with drug exposure and patient outcome in a Phase I anti-angiogenic trial.