Meeting Banner
Abstract #2765

Choline Metabolite Ratios from NMR as Markers of Human Breast Cancer

Mary C. Mahoney1, Jing Huei Lee2, Wen Jang Chu2, John M. Pearce2, Kim M. Cecil3, Stephen M. Strakowski2, Richard A. Komoroski2

1Radiology, University of Cincinnati, Cincinnati, OH, United States; 2Center for Imaging Research, University of Cincinnati, Cincinnati, OH, United States; 3Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

In vivo 1H MRS of breast cancer lesions can detect a signal assigned to total choline (tCho), which arises from a variety of choline-containing metabolites. The contribution of each metabolite to the increased tCho peak in vivo is not known. Here we report in vitro 1H NMR spectroscopy results on fine-needle aspirate (FNA) biopsies of lesions from breast cancer patients, several of whom were also studied by in vivo MRS. Phosphocholine was usually the major metabolite, whereas the contribution of glycerophosphocholine varied substantially, and that of Cho was always minor.