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Abstract #2768

Metabolic Profile of Lipid Extracts Obtained by Astrocytic Brain Tumors

Frauke Nehen1, Wieland Willker1, Laura Columbano2, Rudolf Fahlbusch2, Dieter Leibfritz1

1Institute of Organic Chemistry, University of Bremen, Bremen, Germany; 2International Neuroscience Institute Hannover, Hannover, Germany

Lipophilic tissue extracts of astrocytic brain tumors were analyzed by 1H-NMR spectroscopy. Tumor core, tumor margin and reference tissue differ significantly with respect to their content of galactosyl cerebrosides and one unknown metabolite. Lipid separation with solid phase extraction of eight lipid extracts, enrichment by combining fractions in which the unknown metabolite was observed and analysis by various 2D-NMR methods revealed that the unknown metabolite is an isoprene derivative.