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Abstract #2773

Hyperpolarized 13C Biomarkers of Androgen Independent Prostate Cancer

Paniz Vafaei1, Robert Bok1, Lynn DeLosSantos, Vicki Zhang, Phillip Guan, Dan Vigneron, John Kurhanewicz

1Radiology, University of California, San Francisco, San Francisco, CA, United States

Androgen independence of prostate cancer is an important clinical status to identify, but no well-defined biomarkers for this state exist. In this study we used fast 13C-MRSI after injection of hyperpolarized [1-13C] pyruvate and pathological and biochemical analysis of the tumor to determine hyperpolarized (HP) biomarkers of androgen dependent and androgen independent prostate cancer. Androgen independent phenotype had a significantly higher HP lactate/noise, Total Hyperpolarized Carbon, HP lactate/pyruvate, and LDH activity relative to the androgen dependent phenotype.