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Abstract #2795

Phospholipid Contents Measured in Human Breast Cancer and in Healthy Glandular Breast Tissue in Vivo at 7T

Dennis WJ Klomp1, Bart van de Bank1, Alexander Raaijmakers2, Mies Korteweg1, Cecilia Possanzini3, Vincent Boer1, Nico van de Berg2, Maurice van de Bosch1, Peter Luijten1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2Radiotherapy, University Medical Center Utrecht, Utrecht, Netherlands; 3Philips Health Care

In this work we demonstrate the ability to detect multiple phospholipid metabolites in vivo in the human female breast using focused field coils at 7T. For the first time ever, these signals are detected locally with a spatial resolution of 10 ml. The signals are detected from breast cancer tissue, which has a high concentration of choline levels and even from healthy, glandular breast tissue as well, which has low levels of total choline (i.e. < 0.5 mM).