Dennis WJ Klomp1, Bart van de Bank1,
Alexander Raaijmakers2, Mies Korteweg1, Cecilia
Possanzini3, Vincent Boer1, Nico van de Berg2,
Maurice van de Bosch1, Peter Luijten1
1Radiology, University Medical Center
Utrecht, Utrecht, Netherlands; 2Radiotherapy, University Medical
Center Utrecht, Utrecht, Netherlands; 3Philips Health Care
In
this work we demonstrate the ability to detect multiple phospholipid
metabolites in vivo in the human female breast using focused field coils at
7T. For the first time ever, these signals are detected locally with a
spatial resolution of 10 ml. The signals are detected from breast cancer
tissue, which has a high concentration of choline levels and even from
healthy, glandular breast tissue as
well, which has low levels of total choline (i.e. < 0.5 mM).