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Abstract #2818

Assessment of the Early Response to Chemotherapy with Diffusion-Weighted MRI in Advanced Lung Cancer Patients-Comparison with FDG-PET-

Tatsuro Tsuchida1, Miwa Morikawa2, Yukihiro Umeda2, Masato Sasaki3, Tomohito Kamibayashi1, Hirohiko Kimura1

1Dept. of Radiology, University of Fukui, Fukui, Japan; 2Dept. of Respiratory Medicine, University of Fukui, Fukui, Japan; 3Dept. of Thoracic Surgery, University of Fukui, Fukui, Japan

The purpose of this study was to examine the utility of DWI-MRI for the assessment of early response to chemotherapy in patients with advanced lung cancer by comparing FDG-PET. Twenty-two lung cancer patients received MRI, FDG-PET, and CT examination before and after 1 cycle of chemotherapy. Progression-free survival (PSF) between responder and non-responder against chemotherapy was compared by means of % change of ADC and SUV. Both index indicated that responder demonstrated significant longer PSF and DWI-MRI will be a promising tool for the assessment of the early response to chemotherapy.