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Abstract #2938

A Positive Contrast Method for MR-Lymphography Using Superparamagnetic Iron Oxide Nanoparticles

Haitao Zhu1, Kazuyuki Demachi1

1Department of Nuclear Engineering, The University of Tokyo, Tokyo, Japan

The objective of this work is to apply a post-processing method in MR-lymphography with superparamagnetic iron oxide nanoparticle (SPION) enhancement to achieve positive contrast in the image. The method analyzes the echo position shift caused by susceptibility gradient and uses this criterion to enhance region with large gradient caused by SPIONs. Both phantom and animal experiments are performed to test the method. Results show that this positive contrast method can generate enhanced signal at the region targeted by SPIONs and might provide additional information in MR-lymphography.