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Abstract #2944

Sensitivity of MRI Resonance Frequency to the Orientation of Brain Tissue Microstructure

Jongho Lee1, Karin Shmueli1, Masaki Fukunaga1, Peter van Gelderen1, Hellmut Merkle1, Afonso C. Silva2, Jeff H. Duyn1

1Advanced MRI/LFMI/NINDS, National Institutes of Health, Bethesda, MD, United States; 2CMU/LFMI/NINDS, National Institutes of Health, Bethesda, MD, United States


Here we demonstrate microstructural orientation affects the MRI resonance frequency. The experiment was designed to avoid macroscopic susceptibility effect to identify true microstructural effect. We suggest an origin related to anisotropic susceptibility.

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