Elena Vinogradov1, Alexander Ivanishev1, Aaron K. Grant1, Ron N. Alkalay2, David B. Hackney1, Robert E. Lenkinski1
1Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; 2Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
Quantitative assessment of Glycosaminoglycans (GAGs) in the clinical environment can assist with characterization of disorders associated with cartilage degradation and loss. Sodium imaging and Chemical Exchange Saturation Transfer for GAG detection (gagCEST) are two of the several methods for GAG assessment. Both methods rely on the endogenous effects. However, sodium imaging suffers from low sensitivity and requires specialized hardware. GagCEST is a new method still in the validation phase. Both methods were implemented on the clinical 3T scanner for the purpose of the validation of the techniques and the correlation between GAG state in-vivo as assessed using the two methods.