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Abstract #2986

Improving Amide Proton Transfer Imaging with Dual Echo B0 Mapping for Field Inhomogeneity Correction at 3T

Wenbo Wei1, Guang Jia1, Steffen Sammet1, Peter Wassenaar1, Jinyuan Zhou2, Michael Knopp1

1Department of Radiology, The Ohio State University, Columbus, OH, United States; 2Department of Radiology, Johns Hopkins University, Baltimor, MD, United States

In this study, dual echo B0 mapping was used in Amide Proton Transfer (APT) imaging for correcting B0 inhomogeneity with fewer data points which will lead to approximately one third of the current scan time and thus higher resolution. CEST spectrum, MTRasym curve and MTRasym (3.5ppm) encoded color maps of the proposed APT method were compared to a conventional method. The proposed method offers a more accurate MTR asym curve shape and a better determination of the water resonance frequency which allows a better MTRasym calculation.