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Abstract #3002

Detection of Proton Chemical Exchange Between Metabolites and Water Using T1ρ MRI

Feliks Kogan1, Walter Witschey1, Keijia Cai1, Mohammad Haris1, Ravinder Reddy1

1Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Imaging of chemical exchange processes is important as it allows for quantification of specific metabolites. In this study, we developed a new method based on T1ρ MRI to create image contrast and quantify the exchange of protons between metabolites and water. We showed that this method is responsive to changes in concentration as well as pH. The sensitivity of this technique scales quadratically with static magnetic field and becomes much more valuable as high field magnets become more widely available clinically.