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Abstract #3005

A Fast, Quantitative T1ρ Imaging Method

Timo Liimatainen1, Olli Grhn2

1Department of Biotechnology and Molecular Medicine, University of Kuopio, Kuopio, Finland; 2Department of Neurobiology, University of Kuopio, Kuopio, Finland

A pulse sequence based on gradient echo design was modified to include four hyperbolic secant pulses, following by a signal acquisition. This was repeated four times to obtain a T weighted signal intensity curve with incrementally increasing spin-lock time for single phase encoding step. T relaxation times were compared between developed method and spin echo readout with a T preparation pulse train in mice brains. Similar T values were obtained with both methods. The developed method allows acquisition of several incremented spin-lock times within one repetition time enabling faster quantization of T and/or decreased specific absorption rates.