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Abstract #3007

Measuring T1ρ Changes Related to Acidosis and Alkalosis

Hye Young Heo1, Nader Dahdaleh1, Daniel Thedens1, Bradley Bolster2, John Wemmie1, Vincent Magnotta1

1University of Iowa, Iowa City, IA, United States; 2Siemens Healthcare, Rochester, MN, United States

The purpose of this study is to determine the ability of magnetic resonance (MR) imaging to assess regional pH levels. Both phantom and mouse models were used to evaluate pH sensitive changes in T imaging. A linear relationship was observed between T time and pH. In the mouse model, widespread increases in T times during CO2 inhalation were found consistent with the expected acidosis, whereas reduced T times during HCO3- injection were found to be consistent with the expected alkalosis.