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Abstract #3018

Chemically Selective Asymmetric Spin-Echo EPI Phase Imaging for Internally Referenced MR Thermometry

Markus Nikola Streicher1, Andreas Schfer1, Bibek Dhital1, Dirk Mller1, Robin Martin Heidemann1, Andre Pampel1, Dimo Ivanov1, Robert Turner1

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

We implemented a novel spin-echo EPI sequence that can acquire phase images of different chemically-shifted protons at the same slice positions. Chemical selection was achieved by applying different slice-select gradient amplitudes for excitation and refocusing RF pulses, and phase sensitivity was obtained using an asymmetric EPI readout. MR Thermometry was then performed on a mixture of water and dimethyl sulfoxide (DMSO), which has a proton chemical shift of -2 ppm from water. The two compounds were then imaged alternately, water for temperature sensitivity and DMSO to monitor field changes. Fat can also be selectively imaged as a reference compound.